- Featured Products
- Gene biotherapeutics
- Protein therapeutics
- Resources
As leaders of innovative, reliable HPLC and UHPLC column development for over 40 years, you can trust Thermo ScientificTM columns to meet your needs for complex separations and analyses. Our columns for biomolecule separation – referred to as BioLC columns – were designed for high resolution, enhanced sensitivity, faster analyses, and consistent performance. Browse our recommended columns for your applications below.
- AAV’s
- Aggregates
- Bioanalysis- large molecules
- Charge variants
- Drug discovery/development
- Glycan analysis
- Intact protein/subunit
- Oligonucleotides
- Peptide mapping
Click here to explore our complete Thermo Scientific Chromatography consumables offering.
Advances in genetics and bioengineering have enabled the development of
biotherapeutics with unprecedented potential to treat diseases caused by
recessive gene disorders, acquired genetic diseases, and some viral
infections. Technologies for manufacturing and analysis of gene, mRNA, and
oligonucleotide based biotherapeutics such as chromatographic methods
are evolving with continued efforts to be fully optimized.
Oligonucleotide HPLC Columns
Exceptionally high resolution of +1 and -1 nucleic acids, including isomers
These columns are used in HPLC and UHPLC experiments. What sets Thermo Scientific™ DNAPac™ columns apart from the rest is their ability to provide exceptionally high resolution separations of nucleic acids (+1 and -1), including isomers, which is not possible with reversed phase columns. The larger i.d. columns are popularly used for the small scale purification of nucleic acids.
Protein therapeutics, a class of biotherapeutics, offer advantages over small-molecule drugs by targeting specific functions with reduced adverse effects and immune responses. Analytical approaches and workflows are essential for comprehensive characterization, ensuring product safety and efficacy throughout development and manufacturing.
Catalog Number 10146081
Catalog Number 6183639
Catalog Number 7229290
Catalog Number 6017000
Catalog Number 6366080
Monoclonal Antibody HPLC Columns
Characterization of mAbs and their aggregates, fragments, and titers
Extensive development of protein and monoclonal antibody (mAb) therapeutics currently underway requires innovative and efficient tools that characterize and quantify structural variants and modifications, monitor product stability and demonstrate safety and efficacy. These specifically designed Thermo Scientific™ MAbPac™ columns provide a full range of high resolution, high efficiency mAb analyses by LC and LC-MS.
Protein HPLC Columns
Exceptionally high resolution, high efficiency protein characterization
High resolution and high efficiency set these columns apart. For excellent analytical characterization of proteins, we offer a full range of Thermo Scientific™ affinity, ion exchange, reversed phase, hydrophobic interaction, and size exclusion columns for your protein sample.
Glycan HPLC Columns
Exceptional characterization, purification and isolation
Mixed-mode Thermo Scientific™ GlycanPac™ columns provide uniquely exceptional high resolution separation of neutral and charged glycans. In addition, we offer traditional amide-HILIC columns for the separation of neutral glycans, and ligand exchange columns for the purification and isolation of carbohydrates using an affinity support.
